Sanders' "Bye, Bye, Barry" just hit Prime Video this week ... and Mitchell's big takeaway was that many guests featured in the doc blamed him for the running back never winning a Super Bowl.

Mitchell went to Facebook to vent about it all ... initially praising Sanders' abilities on the field, before ripping into his critics -- name-dropping Detroit superfans Eminem and Jeff Daniels in the process.

"However, I am so tired of hearing how I was the reason that Barry Sanders never won a Super Bowl," Mitchell said, according to the Detroit News. "I'm so tired of hearing how I was not a good QB. My only response is F*** YOU ALL!!!!! That includes Eminem (and) Jeff Daniels."

Mitchell -- who played for the Lions from 1994-98 -- added he was disappointed to hear his former coach, Wayne Fontes, openly talk about wishing he had Joe Montana or Warren Moon under center instead ... and how a proper QB was what kept Barry from being a champion.

"A little support from the coach might have gone a long way," Mitchell added. "Wayne never had my back!"

Mitchell then turned his focus to Sanders ... saying he, too, deserved blame for their empty trophy cases.

"Bottom line, Barry Sanders had everything in Detroit," Mitchell continued. "Everyone loved him. Everything was built for Barry to succeed. In his 10 year career, he won one playoff game and the only reason he didn't win more was everyone else was the problem?"

"How many yards did Barry have in the playoffs in '94, '95, '97? I'll give you a hint not very many. We all are to blame for not winning a (Super Bowl) in Detroit even Barry Sanders."

Mitchell ended his rant by saying he truly feels the Lions could have gone the distance if the team had just been a bit more patient ... but that's not how it played out.