The triple threat star -- famous for her show 'Insecure' -- was doing a sit-down Saturday at the CultureCon conference in NYC ... where she was about to answer questions from moderator Glenda McNeal, who's a bigwig over at AmEx.

As McNeal intro'd Issa ... she kinda botched her first name, calling her Ih-suh as opposed to Ee-suh (the correct way to say it). Just as quickly, she was informed by the crowd.

Take a look for yourself ... there was a chorus of "Issa" from the audience, with multiple people shouting out and interruption McNeal's train of thought to let her know she'd said it wrong -- and it clearly took the speaker by surprise, and ditto for IR herself.

McNeal corrected herself, and then apologized ... saying she'd made a mistake, noting she was part of the Black community and meant no harm. Issa seemed to find it hilarious.

No harm, no foul big picture -- but it is a testament to something in the grand scheme of things. Fact is, we're reaching a point when perceived disrespect simply won't be tolerated ... especially among beloved celebs like Issa, who's star is growing brighter by the day.