The legendary rapper unloaded fiery disses on The Game, Melle Mel -- and Generation Z rap fans too young to remember his heyday -- after they've all been dragging his name through the mud.

The lyrical retaliation arrived Friday on the track "Realest" -- the debut single for Em and Dr. Dre's new artist Ez Mil -- but it was Slim Shady who stole the show.

As we reported last year, Game spent a full 10 minutes dissing Em on his last album and later claimed superiority over him for never having his songs played in the club.

Em says Game's songs only get club play because those are the range of his performance bookings and is a little jelly of his career. Melle Mel also got shredded by Em, after having boosted his profile earlier this year by ripping Em for being a white rapper who benefits from the audience majority share.

Em openly admits to being a "guest" in Hip Hop on the track, a term used to acknowledge Black culture birthed Hip Hop … but points out how his success helped the genre boom across the globe.

He proceeded to roast Melle's gym rat legacy with a clever jab at the notion he uses steroids rapping, "And I’ll be the last to toy with a juice-head whose brain is like half destroyed like a meteor hit it/ Well, there went Melle Mel, we lost his ass to 'roids." Get it? Asteroids!!! ☄

The young whippersnappers of Gen Z who criticize Em arguably felt the worst of his wrath ... some of them weren't even born when he dropped his first studio album back in 1999, and Em coldly credited their era for elevating the country's school shootings!!!

"Y'all need to stick to what you do best/Shootin' schools up, gat/Go load up rounds in your parents' gats, and go to class and let off with the strap and go to town," Em fumed at the kids.