DeSantis made the big announcement Wednesday on the bird app ... dropping a campaign video that takes jabs at President Biden, blaming him for crime-filled streets and conflict at the border. He goes on to say he's the guy to lead the "great American comeback."

Of course, DeSantis was slated to drop the big news in a Twitter Spaces chat with Elon ... but apparent technical issues forced hundreds of thousands of listeners to listen as moderator David Sacks' audio kept cutting in and out.

Elon can be heard saying Twitter's servers are struggling to keep up -- and folks on the very same app are dragging him and the whole thing for the big mess ... with one calling it a "car crash," while another calling DeSantis' failed attempt "a perfect metaphor."

Even Biden took a jab at the whole thing -- with a tweet to his donation page that reads, "This link works."

You'll recall, TMZ confirmed Elon was set to join DeSantis for the declaration -- something that appears to be a push to make the app feel more like regular TV. Elon also called on ex-CNN anchor Don Lemon to start a show on his platform after Tucker Carlson said he'd be doing the same. Obviously, this mess might make Elon reconsider.

As for DeSantis, he's been seen as one of the only candidates that stands a chance at knocking down former President Donald Trump -- who announced his bid for the 2024 seat back in November.

DeSantis picking Twitter for his announcement spot doesn't just set him apart from the rest of his competition, but it appears to be a big "F-U" to Trump ... who infamously was taken off the platform after the Jan. 6 insurrection.