10:18 AM PT -- Alexis Ohanian has entered the chat -- the Reddit co-founder hinted at the diss in a Twitter thread about his recent accomplishments ... including being a father and husband.
"The reason I stay winning is because I'm relentless about being the absolute best at whatever I do -- including being the best groupie for my wife & daughter." Ohanian said.
Serena Williams responded to the message with several heart-smiley emojis.
Drake wasn't only going after Megan Thee Stallion on his new album ... Serena Williams' husband was also name-dropped -- getting called a straight-up "groupie" in a new song.
The OVO rapper released his 16-track joint album, "Her Loss," with 21 Savage on Friday ... and the superstar's hubby, Alexis Ohanian, might not be a fan of a certain track called "Middle of the Ocean."
Here's what he says around the 3:35 mark:
"Sidebar, Serena, your husband a groupie
He claim we don't got a problem but
No, boo, it is like you comin' for sushi"
Fans went crazy over the bars on social media -- one person called Drake petty and another said Ohanian deserved it, as he's seemingly taken subtle jabs at the rapper in the past.
Remember, Drake and Serena were a thing back in the day -- TMZ Sports obtained pictures of them kissing in a fancy restaurant in 2015 ... before Ohanian was in the picture.
Drake also went to Williams' Wimbledon match in 2018 ... cheering her on from the crowd.
FYI, this ain't the first time Drake has mentioned Williams in his lyrics -- in his "Worst Behavior" song from 2013, he talks about the tennis legend:
"I'm with my whole set, tennis matches at the crib
I swear I could beat Serena when she playin' with her left."
Williams and Ohanian have not responded to Drake's diss ... but Meg did call him out for targeting her in the "Circo Loco" track.
Happy Friday, everyone!!!
Originally Published -- 8:52 AM PT