Paul George is out ... the Clippers star has entered the league's health & safety protocols and will miss tonight's game against the New Orleans Pelicans.

... a gigantic blow for the Clips.

Adrian Wojnarowski reports sources told him the L.A. forward will not play in his team's win-or-go game against the Pelicans.

It's unclear if PG tested positive for COVID or is just experiencing symptoms, but either way the 7x All-Star won't be seeing the court in the biggest game of the season.

George was already sidelined for a number of games for the Clippers this season ... as he was dealing with a torn ligament in his elbow.

However, since returning to the Clips lineup, the team has enjoyed some success with one of the game's premier two-way players back in the mix.

George averaged over 24.3 points per game, 6.9 assists, and 5.7 rebounds despite only playing in 31 games for the Clippers this season.

The Clippers will have an uphill battle if they want to get past a tough New Orleans team ... and losing one of their best players certainly won't make it any easier.

Story developing ...