TMZ Sports has learned ... a basketball card featuring Michael Jordan and Kobe Bryant has hit the auction block with PWCC Marketplace ... and could come with a massive price tag.

This piece of NBA memorabilia features both superstars' John Hancocks ... as well as a piece of both Jordan and Bryant's game-worn jerseys.

PWCC describes the card as "the single most desirable" card from Upper Deck's Series 2 release in 2000 ... and the first to feature both Black Mamba and His Airness.

The card's in great shape -- it's been stamped 9/10 on the grading scale ... and has been preserved in a Beckett 8 holder to ensure it remains in mint condition.

PWCC Exec Jesse Craig tells us it's very rare that an item like this comes up to auction ... and that only 10 copies of this card were made.

"One of the things that is just so impressive about this card is that it exists at all," Craig said. "Jordan was an obvious legend by this time, but Kobe’s greatness was just getting started."

"We look back at the totality of the careers now and the connection is obvious, but at the time it still required some imagination to craft an asset such as this."

MJ and Kobe became tight over the years ... and the Chicago Bulls legend even spoke at Bryant's funeral in February 2020.

The PWCC auction is currently live ... and ends on February 19. No official word on what the card will go for, but we're told this same card recently sold for $516k!!!