The Buffalo Bills wide receiver honored the iconic actress Sunday with a pair of pregame footwear that featured BW's likeness, plus a famous song attributed to her as well. You can see a cartoon rendering of Betty throwing up the 'rock on' hand sign ... while smirking.

On the other cleat, the words "Thank You For Being a Friend" are emblazoned -- obviously a nod to the 'Golden Girls' theme song of the same name. The artwork was done by footwear designer Mache, who's famous for doing these mockups for athletes, especially Stefon.

No word if these babies made it on the gridiron or not -- SD usually flashes his custom cleats before kickoff, and then changes into what he'll actually wear for the game. But, it's not unheard of for him to rock tribute cleats on the field, like he did for Michael K. Williams.

Anyway, it's clear Betty left her mark on Stefon ... who proved himself to be a fan with a tweet he sent on the day she passed. He simply wrote, "Rip Betty White" ... and now, his love for her comes full circle.

We broke the story ... Betty died on New Year's Eve, not far from what would've been her 100th birthday this month.