Wentz was shipped to Indianapolis in exchange for a couple draft picks earlier this week ... officially ending his 5-year career with the Eagles.

The 28-year-old bid farewell to his first NFL home on Friday in a lengthy message, saying, "As one chapter closes, another one begins."

Wentz first thanked his Eagles teammates -- "I appreciate every one of you and will never forget the relationships and memories made over the years."

"So many lifelong relationships have been formed in that locker room. Thank you for the fellowship, the camaraderie in the locker room, and the daily battles out on the practice field!"

Wentz then showed love to the city of Philly ... adding, "You have been my home for the past five years. It has been everything a kid from Bismarck, North Dakota could have dreamed of."

"My family grew here, had a lot of fun, ate a lot of great food, got to be a part of an incredible church, and so many more memories off the field."

He continued ... "On the field, we brought the Lombardi trophy home to Philly and hopefully brought a lot of joy to the city over the years."

"Thank you to the amazing Eagles fans across the World that have supported my family, our foundation, and our football team through all of the wins and losses. It was an honor to play in a city whose passion and love for their football team is unrivaled."

Lastly, Wentz thanked the team that drafted him #2 overall back in 2016 and making his NFL dream a reality -- "Thank you Mr. Lurie, Howie Roseman & the Eagles front office, Coach Pederson & all of my coaches, our training staff, our equipment staff and all of the support staff at the Nova Care Complex."

"It has been an amazing journey and I wish you all the best."

Wentz says he's stoked for the new journey ahead with the Colts ... and it's easy to believe it -- he's already reached out to his new teammates via text and FaceTime!!