She was the guest Saturday on Candace Owens' show when the ultra-conservative host lit the fuse by saying she was sick of "Lena Dunham types going around saying we want this now, now, now." She added ... the whole "believe women thing" was out of control.

Then Roseanne tapped in, taking a shot at women who complain about sexual misconduct years later. She said they should've run out of the room ... "But, you stayed around 'cause you're like, 'Well, I thought maybe he was gonna give me a writing job.' Well, you ain't nothing but a ho."

The fireworks were just beginning. Roseanne also dragged Mike Tyson into it, saying he calls #MeToo, You Too ... because it will eventually get you.

And, then there was her take on anti-Semitism in middle America -- or as she puts it, "obese people from the Midwest."