The rapper held a listening party Thursday night for a new album which includes a song with these lyrics -- "I held Kim Kardashian by the throat, n***a. I made her swallow my kids until she choked, n***a."

The lyrics are gonna be a big deal -- not just because Kim might be pissed, but because Kanye will almost definitely go nuclear. We already know he doesn't take kindly to other dudes talking about his wife ... especially in a sexual manner.

Last year, he blasted Nick Cannon for doing it during an interview, and called out Drake for not squashing speculation she was Keke in "In My Feelings."

Game's lyric about Kim is followed by the line, "I should apologize cause Ye my folks, n***a."

Based on his history, we're guessing Ye won't give a crap about that apology.

For the record, Game and Kim did date in the past. He once claimed, on a track, to have banged all 3 Kardashian sisters, but they said he's lying -- he's only 1 for 3.