The "Kream" rapper's first run with a professional baller didn't go so well ... she had a disastrous breakup with Nick Young -- and things didn't look promising for other athletes.

But ... apparently she's willing to give it another shot -- with one of football's best players!!

"Yeah, we're in a relationship," Iggy said of Hopkins to Y100 in Miami.

There had been rumors about the two for a week or so ... especially after the Texans star was awfully flirty with her in some of his IG posts.