A game-worn jersey from Wayne's insane record-setting 1979-80 season is hitting the auction block and experts believe the bidding could hit the $400k range.

Remember, Wayne LIT UP the NHL during his first year in the NHL -- scoring 51 goals, leading all 1st-year NHL players in points and assists ... and winning league MVP.

Dude was unreal.

Now, Goldin Auctions has an authentic autographed game-worn uni from that legendary season ... and it's hitting the auction block with a starting price of $125,000.

Of course, Gretzky went on to be the greatest hockey player that ever lived ... his 894 career goals are nearly 100 more than second place on the all-time list!!

Goldin tells TMZ Sports ... they were able to authenticate the jersey, in part, by using photos to match up markings, tears, and other imperfections on the item.