It's unclear if KiKi loves Drake -- but one thing's for sure ... he definitely loved one little girl's "KiKi Challenge," 'cause he made a point to visit her in Chicago.

Drake stopped by the Lurie Children's Hospital of Chicago Monday to meet up with 11-year-old Sofia Sanchez -- who turned 11 on Saturday. Her birthday wish -- to meet Drizzy.

She got on Drake's radar after she posted an "In My Feelings" dance video ... weeks after undergoing open heart surgery and waiting for a heart transplant.

Sources close to the rapper tell us Drake saw the video and wanted to oblige, so he swung by the hospital to meet her.

We're told he spent an hour in her room and they talked about a lot ... from his music, her love of cheerleading and their shared interests (Bieber, owls, and basketball). They even touched on her GoFundMe page.

Me and my love Sofia talking about Bieber and Owls and Basketball💙💙💙

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Oh, and for good measure ... we're told Drake and Sofia even sang his song together. Now that's a heck of a birthday present.