LeBron James has weighed in on the deadly shooting in Las Vegas -- saying he's praying for the victims ... while asking the question, "What the hell is going on people!?!?"

"Pray for Vegas!" James tweeted ... "What the hell is going on people!?!? My prayers sent to the heavens above for all the families."

Philadelphia Eagles QB Carson Wentz also commented -- saying, "So much hate and evil. So sad. The World needs Jesus in a bad way. Praying for all those affected in Vegas."