Kim, Khloe and Kylie will make you a small fortune if they all pop out a bunch of baby boys ... but the odds are STACKED.

The gambling site BetOnline.ag -- one of the biggest gambling sites -- will pay out $3,300 for your $100 bet if they all give birth to boys. But as TMZ's reported ... Kim's surrogate is having a girl and Kylie's telling friends she's having a girl. So ... good luck with that.

But there are some safer bets:

+300 if they all have girls

+1400 if Kim's baby begins with K

+450 if Tyga tweets congrats to Kylie

+240 if Khloe's kid weighs under 7.5 lbs.